研究業績

2024 | 2023 | 2022 | 2021以前 | 2011以前 |

2024

  • Fujimoto K, Hayashi T, Yamamoto M, Sato N, Shimohigoshi M, Miyaoka D, Yokota C, Watanabe M, Hisaki Y, Kamei Y, Yokoyama Y, Yabuno, Hirose A, Nakamae M, Nakamae H, Uematsu M, Sato S, Yamaguchi K, Furukawa Y, Akeda Y, Hino M, Imoto S, Uematsu S.
    An enterococcal phage-derived enzyme suppresses graft-versus-host disease.
    Nature. 2024 July 10. doi: 10.1038/s41586-024-07667-8.
  • Watanabe M, Uematsu M, Fujimoto K, Hara T, Yamamoto M, Miyaoka D, Yokota C, Kamei Y, Sugimoto A, Kawasaki N, Yabuno T, Sato N, Sato S, Yamaguchi K, Furukawa Y, Tsuruta D, Okada F, Imoto S, Uematsu S.
    Targeted lysis of Staphylococcus hominis linked to axillary osmidrosis using bacteriophage-derived endolysin.
    J Invest Dermatol. 2024 Apr 18:S0022-202X(24)00294-X. doi: 10.1016/j.jid.2024.03.039.
  • Khamrin P, Kumthip K, Yodmeeklin A, Okitsu S, Motomura K, Sato S, Ushijima H, Maneekarn N.
    Genetic recombination and genotype diversity of norovirus GI in children with acute gastroenteritis in Thailand, 2015-2021.
    J Infect Public Health. 2024 Jan 12;17(3):379-385. doi: 10.1016/j.jiph.2024.01.009.

2023

  • Hattori-Muroi K, Naganawa-Asaoka H, Kabumoto Y, Tsukamoto K, Fujisaki Y, Fujimura Y, Komiyama S, Kinashi Y, Kato M, Sato S, Takahashi D and Hase K.
    α-Glucosidase inhibitors boost gut immunity by inducing IgA responses in Peyer’s patches.
    Front Immunol. 2023 Nov 1; 14:1277637. doi: 10.3389/fimmu.2023.1277637.
  • Yokota C, Fujimoto K, Yamakawa N, Kono M, Miyaoka D, Shimohigoshi M, Uematsu M, Watanabe M, Kamei Y, Sugimoto A, Kawasaki N, Yabuno T, Okamura T, Kuroda E, Hamaguchi S, Sato S, Hotomi M, Akeda Y, Ishii KJ, Yasutomi Y, Sunami K, Uematsu S.
    Prime-boost-type PspA3?+?2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci.
    Inflamm Regen. 2023 Nov 15;43(1):55. doi: 10.1186/s41232-023-00305-2.
  • Matsumoto N, Kurokawa S, Tamiya S, Nakamura Y, Sakon N, Okitsu S, Ushijima H, Yuki Y, Kiyono H, Sato S (Corresponding).
    Replication of human sapovirus in human induced pluripotent stem cell-derived intestinal epithelial cells.
    Viruses. 2023; 15(9):1929. doi:10.3390/v15091929.
  • *Tokunoh N, *Tamiya S, Watanabe M, Okamoto T, Anindita J, Tanaka H, Ono C, Hirai T, Akita H, Matsuura Y, Yoshioka Y. (*equally contributed)
    A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice.
    Front Immunol. 2023 Aug 31;14:1224634. doi: 10.3389/fimmu.2023.1224634.
  • Minami S, Matsumoto N, Omori H, Nakamura Y, Tamiya S, Nouda R, Nurdin JA, Yamasaki M, Kotaki T, Kanai Y, Okamoto T, Tachibana T, Ushijima H, Kobayashi T, Sato S (Corresponding).
    Effective SARS-CoV-2 replication of monolayers of intestinal epithelial cells differentiated from human induced pluripotent stem cells.
    Sci Rep. 2023 Jul 18;13(1):11610. doi: 10.1038/s41598-023-38548-1.
  • Hoque SA, Kotaki T, Pham NTK, Onda Y, Okitsu S, Sato S, Yuki Y, Kobayashi T, Maneekarn N, Kiyono H, Hayakawa S, Ushijima H.
    Genotype Diversity of Enteric Viruses in Wastewater Amid the COVID-19 Pandemic.
    Food Environ Virol. 2023 Apr 14:1–16. doi: 10.1007/s12560-023-09553-4.
  • Takahashi Y, Inoue Y, Sato S, Okabe T, Kojima H, Kiyono H, Shimizu M, Yamauchi Y, Sato R.
    Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies.
    Sci Rep. 2023 Apr 3;13(1):5407. doi: 10.1038/s41598-023-32438-2.
  • Hoque SA, Kotaki T, Pham NTK, Onda Y, Okitsu S, Sato S, Yuki Y, Kobayashi T, Maneekarn N, Kiyono H, Hayakawa S, Ushijima H.
    Abundance of Viral Gastroenteritis before and after the Emergence of COVID-19: Molecular Evidence on Wastewater.
    J Infect. 2023 Feb;86(2):154-225. doi: 10.1016/j.jinf.2022.11.007.
  • Nurdin JA, Kotaki T, Kawagishi T, Sato S, Yamasaki M, Nouda R, Minami S, Kanai Y, Kobayashi T.
    N-Glycosylation of Rotavirus NSP4 Protein Affects Viral Replication and Pathogenesis.
    J Virol. 2023 Jan 31;97(1):e0186122. doi: 10.1128/jvi.01861-22.
  • Masuda A, Man Lee J, Miyata T, Sato S, Masuda A, Taniguchi M, Fujita R, Ushijima H, Morimoto K, Ebihara T, Hino M, Kakino K, Mon H, Kusakabe T.
    High yield production of norovirus GII.4 virus-like particles using silkworm pupae and evaluation of their protective immunogenicity.
    Vaccine. 2023 Jan 16;41(3):766-777. doi: 10.1016/j.vaccine.2022.12.015.

2022

  • Yuki Y, Zuo F, Kurokawa S, Uchida Y, Sato S, Sakon N, Hammarstr?m L, Kiyono H, Marcotte H.
    Lactobacilli as a Vector for Delivery of Nanobodies against Norovirus Infection.
    Pharmaceutics. 2022 Dec 25;15(1):63. doi: 10.3390/pharmaceutics15010063.
  • Ishihara N, Nakamura Y, Yakabe K, Komiyama S, Fujimura Y, Kaisho T, Kimura S, Hase K.
    Spi-B alleviates food allergy by securing mucosal barrier and immune tolerance in the intestine.
    Front Allergy. 2022 Oct 6;3:996657. doi: 10.3389/falgy.2022.996657.
  • Noguchi M, Shimizu M, Lu P, Takahashi Y, Yamauchi Y, Sato S, Kiyono H, Kishino S, Ogawa J, Nagata K, Sato R.
    Lactic acid bacteria-derived γ-linolenic acid metabolites are PPARδ ligands that reduce lipid accumulation in human intestinal organoids.
    J Biol Chem. 2022 Sep 23:102534. doi: 10.1016/j.jbc.2022.102534.
  • Takahashi Y, Noguchi M, Inoue Y, Sato S, Shimizu M, Kojima H, Okabe T, Kiyono H, Yamauchi Y, Sato R.
    Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies.
    iScience. 2022 June 15;25(7): 104542. doi: 10.1016/j.isci.2022.104542.
  • Pham NTK, Nishimura S, Shimizu-Onda Y, Trinh QD, Komine-Aizawa S, Khamrin P, Okitsu S, Sato S, Kobayashi T, Maneekarn N, Hayakawa S, Ushijima H.
    Emerging norovirus GII.4 Sydney[P31] causing acute gastroenteritis outbreak in children in Japan, during COVID-19, 2021.
    J Infect Chemother. 2022 Jun 1:S1341-321X(22)00164-7. doi: 10.1016/j.jiac.2022.05.015.
  • Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, Sasai M, Torii S, Ono C, Shichinohe S, Sato S, Wakita M, Okumura S, Nakano S, Matsudaira T, Matsumoto T, Kawamoto S, Yamamoto M, Watanabe T, Matsuura Y, Takayama K, Kobayashi T, Okamoto T, Hara E.
    SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response.
    Nat Aging. in press. doi: 10.1038/s43587-022-00170-7.
  • Kamioka M, Goto Y, Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H.
    Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense.
    Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2115230119. doi: 10.1073/pnas.2115230119.

2021

  • Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, Sato S, Yoshida Y, Tsuji S, Uemura K, Wakita M, Matsudaira T, Matsumoto T, Kawamoto S, Takahashi A, Itatani Y, Miki H, Takamatsu M, Obama K, Takeuchi K, Suematsu M, Ohtani N, Fukunaga Y, Ueno M, Sakai Y, Nagayama S, Hara E.
    Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.
    Nat Commun. 2021 Sep 28;12(1):5674. doi: 10.1038/s41467-021-25965-x.
  • Usami K, Niimi K, Matsuo A, Suyama Y, Sakai Y, Sato S, Fujihashi K, Kiyono H, Uchino S, Furukawa M, Islam J, Ito K, Moriya T, Kusumoto Y, Tomura M, Hovey RC, Sugawara J, Yoneyama H, Kitazawa H, Watanabe K, Aso H, Nochi T.
    The gut microbiota induces Peyer's-patch-dependent secretion of maternal IgA into milk.
    Cell Rep. 2021 Sep 7;36(10):109655. doi: 10.1016/j.celrep.2021.109655.
  • Takahashi Y, Inoue Y, Kuze K, Sato S, Shimizu M, Kiyono H, Yamauchi Y, Sato R.
    Comparison of gene expression and activation of transcription factors in organoid-derived monolayer intestinal epithelial cells and organoids.
    Biosci Biotechnol Biochem. 2021 Jul 23:zbab136. doi: 10.1093/bbb/zbab136. Epub ahead of print.
  • *Sasou A, *Yuki Y, *Kurokawa S, *Sato S, Goda Y, Uchida M, Matsumoto N, Sagara H, Watanabe Y, Kuroda M, Sakon N, Sugiura K, Nakanishi-Ouchida R, Ushijima H, Fujihashi K, Kiyono H. (*equally contributed)
    Development of antibody-fragment–producing rice for neutralization of human norovirus.
    Front Plant Sci. doi: 10.3389/fpls.2021.639953.

2020

  • Sato S (Corresponding), Matsumoto N, Hisaie K, Uematsu S.
    Alcohol abrogates human norovirus infectivity in a pH-dependent manner.
    Sci. Rep. Sci Rep. 2020 Sep 28;10(1):15878. doi: 10.1038/s41598-020-72609-z.
  • Fujimoto K, Kimura Y, Shimohigoshi M, Satoh T, Sato S, Tremmel G, Uematsu M, Kawaguchi Y, Usui Y, Nakano Y, Hayashi T, Kashima K, Yuki Y, Yamaguchi K, Furukawa Y, Kakuta M, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S.
    Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts.
    Cell Host Microbe. 2020 Sep 9;28(3):380-389.e9. doi: 10.1016/j.chom.2020.06.005.
  • *Yuki Y, *Kurokawa S, *Sato S, Sasou A, Matsumoto N, Suzuki A, Sakon N, Goda Y, Takeyama N, Miyoshi T, Marcotte H, Tanaka T, Hammarstrom L, Kiyono H. (*equally contributed)
    A heterodimeric antibody fragment for passive immunotherapy against norovirus infection.
    J Infect Dis. 2020 Jul 6;222(3):470-478. doi: 10.1093/infdis/jiaa115.
  • Kimura S, Nakamura Y, Kobayashi N, Shiroguchi K, Kawakami E, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, Kaisho T, Iwanaga T, Hase K.
    Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
    Nat Commun. 2020 Jan 13;11(1):234. doi: 10.1038/s41467-019-13883-y.

2019

  • Takahashi I, Hosomi K, Nagatake T, Tobou H, Yamamoto D, Hayashi I, Kurashima Y, Sato S, Shibata N, Goto Y, Maruyama F, Nakagawa I, Kuwae A, Abe A, Kunisawa J, Kiyono H.
    Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia.
    Int Immunol. 2019 Oct 20. pii: dxz071. doi: 10.1093/intimm/dxz071. [Epub ahead of print]
  • Joo S, Suwanto A, Sato A, Nakahashi-Ouchida R, Mori H, Uchida Y, Sato S, Kurashima Y, Yuki Y, Fujihashi K, Kawaguchi Y, Kiyono H.
    A role for the CCR5–CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization.
    Mucosal Immunol. 2019 Nov;12(6):1391-1403. doi: 10.1038/s41385-019-0203-z.
  • Nagai M, Noguchi R, Takahashi D, Morikawa T, Koshida K, Komiyama S, Ishihara N, Yamada T, Kawamura YI, Muroi K, Hattori K, Kobayashi N, Fujimura Y, Hirota M, Matsumoto R, Aoki R, Tamura-Nakano M, Sugiyama M, Katakai T, Sato S, Takubo K, Dohi T, Hase K.
    Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses.
    Cell. 2019 Aug 22;178(5):1072-1087.e14. doi:10.1016/j.cell.2019.07.047.
  • Kimura S, Kobayashi N, Nakamura Y, Kanaya T, Takahashi D, Fujiki R, Mutoh M, Obata Y, Iwanaga T, Nakagawa T, Kato N, Sato S, Kaisho T, Ohno H, Hase K.
    Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice.
    J Exp Med. 2019 Apr 1;216(4):831-846. doi:10.1084/jem.20181604.
  • Sato S (Corresponding), Hisaie K, Kurokawa S, Suzuki A, Sakon N, Uchida Y, Yuki Y, Kiyono H.
    Human norovirus propagation in human induced pluripotent stem cell-derived intestinal epithelial cells
    Cell Mol Gastroenterol Hepatol. 2019;7(3):686-688.e5. doi: 10.1016/j.jcmgh.2018.11.001.

2018

  • Murase M, Kawasaki T, Hakozaki R, Sueyoshi T, Putri DDP, Kitai Y, Sato S, Ikawa M, Kawai T.
    Intravesicular Acidification Regulates Lipopolysaccharide Inflammation and Tolerance through TLR4 Trafficking.
    J Immunol. 2018 Apr 15;200(8):2798-2808. doi: 10.4049/jimmunol.1701390.
  • Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S.
    Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.
    Sci Transl Med. 2018 Feb 21;10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333.
  • Shibata N, Kunisawa J, Hosomi K, Fujimoto Y, Mizote K, Kitayama N, Shimoyama A, Mimuro H, Sato S, Kishishita N, Ishii KJ, Fukase K, Kiyono H.
    Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity
    Mucosal Immunol.
    2018 May;11(3):693-702. doi: 10.1038/mi.2017.103.
  • Takahashi Y, Sato S (Corresponding), Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H.
    A refined culture system for human induced pluripotent stem cell-derived intestinal epithelial organoids.
    Stem Cell Rep. 2018 Jan 9;10(1):314-328. doi: 10.1016/j.stemcr.2017.11.004.
  • Niimi K, Usami K, Fujita Y, Abe M, Furukawa M, Suyama Y, Sakai Y, Kamioka M, Shibata N, Park EJ, Sato S, Kiyono H, Yoneyama H, Kitazawa H, Watanabe K, Nochi T, Aso H.
    Development of immune and microbial environments is independently regulated in the mammary gland
    Mucosal Immunol. 2018 May;11(3):643-653. doi: 10.1038/mi.2017.90.

2017

  • Takahashi Y, Sato S (Corresponding), Kurashima Y, Lai CY, Otsu M, Hayashi M, Yamaguchi T, Kiyono H.
    Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells.
    EBioMedicine. 2017 Sep;23:34-45. doi: 10.1016/j.ebiom.2017.07.027.
  • *Kishikawa S, *Sato S (Corresponding), Kaneto S, Uchino S, Kohsaka S, Nakamura S, Kiyono H. (*equally contributed)
    Allograft inflammatory factor 1 is a regulator of transcytosis in M cells.
    Nat Commun. 2017 Feb 22;8:14509. doi: 10.1038/ncomms14509.

2015

  • Okada K, Sato S, Sato A, Mandelboim O, Yamasoba T, Kiyono H.
    Identification and Analysis of Natural Killer Cells in Murine Nasal Passages.
    PLoS One. 2015 Nov 17;10(11):e0142920. doi: 10.1371/journal.pone.0142920.
  • Goto Y, Lamichhane A, Kamioka M, Sato S, Honda K, Kunisawa J, Kiyono H.
    IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut.
    Sci Rep. 2015 Nov 2;5:15918. doi: 10.1038/srep15918.
  • Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, Ito K, Shimojou M, Matsumoto N, Suzuki H, Kunisawa J, Kiyono H.
    Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse.
    PLoS One. 2015 May 22;10(5):e0127460. doi: 10.1371/journal.pone.0127460.
  • Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K.
    The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells.
    Immunity. 2015 Feb 17;42(2):279-93. doi: 10.1016/j.immuni.2015.01.015.
  • Sato S, Kiyono H, Fujihashi K. (Review article)
    Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review.
    Gerontology. 2015;61(4):336-42. doi: 10.1159/000368897.
  • Suenaga F, Ueha S, Abe J, Kosugi-Kanaya M, Wang Y, Yokoyama A, Shono Y, Shand FH, Morishita Y, Kunisawa J, Sato S, Kiyono H, Matsushima K.Loss of Lymph Node Fibroblastic Reticular Cells and High Endothelial Cells Is Associated with Humoral Immunodeficiency in Mouse Graft-versus-Host Disease.
    J Immunol. 2015 Jan 1;194(1):398-406. doi: 10.4049/jimmunol.1401022.

2014

  • Okura H, Sato S (Corresponding), Kishikawa S, Kaneto S, Nakashima T, Yoshida N, Takayanagi H, Kiyono H.
    Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids.
    PLoS One. 2014 Sep 22;9(9):e108294. doi:10.1371/journal.pone.0108294.
  • Sato A, Suwanto A, Okabe M, Sato S, Nochi T, Imai T, Koyanagi N, Kunisawa J, Kawaguchi Y, Kiyono H.
    Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease.
    J Virol. 2014 Dec;88(23):13699-708. doi: 10.1128/JVI.02279-14.
  • Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H.
    Innate lymphoid cells regulate intestinal epithelial cell glycosylation.
    Science.2014 Sep 12;345(6202):1254009. doi: 10.1126/science.1254009.
  • Kurashima Y, Amiya T, Fujisawa K, Shibata N, Suzuki Y, Kogure Y, Hashimoto E, Otsuka A, Kabashima K, Sato S, Sato T, Kubo M, Akira S, Miyake K, Kunisawa J, Kiyono H.
    The Enzyme Cyp26b1 Mediates Inhibition of Mast-Cell Activation by Fibroblasts to Maintain Skin-Barrier Homeostasis.
    Immunity. 2014 Apr 17;40(4):530-41. doi: 10.1016/j.immuni.2014.01.014.
  • Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda K.
    Generation of colonic IgA-secreting cells in the caecal patch.
    Nat Commun.2014 Apr 10;5:3704. doi: 10.1038/ncomms4704.
  • Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T.
    Peyer's Patches Play a Protective Role in Nonsteroidal Anti-inflammatory Drug-induced Enteropathy in Mice.
    Inflamm Bowel Dis.2014 May;20(5):790-9. doi: 10.1097/MIB.0000000000000017
  • Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S.
    Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
    Nat Commun.2014 Mar 18;5:3492. doi: 10.1038/ncomms4492.
  • Fujihashi K, Sato S, Kiyono H. (Review article)
    Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly.
    Exp Gerontol.2014 Jun;54C:21-26. doi: 10.1016/j.exger.2014.01.006.

2013

  • Obata T, Shibata N, Goto Y, Ishikawa I, Sato S, Kunisawa J, Kiyono H.
    Critical Role of Dendritic Cells in T Cell Retention in the Interfollicular Region of Peyer's Patches.
    J Immunol. 2013 Jul 15;191(2):942-8. doi: 10.4049/jimmunol.1200636.
  • Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K.
    An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing.
    Nat Commun. 2013 Jun 11;4:1949. doi: 10.1038/ncomms2949
  • Kong IG, Sato A, Yuki Y, Nochi T, Takahashi H, Sawada S, Mejima M, Kurokawa S, Okada K, Sato S, Briles DE, Kunisawa J, Inoue Y, Yamamoto M, Akiyoshi K, Kiyono H.
    Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae.
    Infect Immun. 2013 May;81(5):1625-34. doi: 10.1128/IAI.00240-13.
  • Sato S, Kaneto S, Shibata N, Takahashi Y, Okura H, Yuki Y, Kunisawa J, Kiyono H.
    Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells.
    Mucosal Immunol. 2013 Jul;6(4):838-46. doi:10.1038/mi.2012.122.FEATURED ARTICLES

2012

  • Zhao H, Konishi A, Fujita Y, Yagi M, Ohata K, Aoshi T, Itagaki S, Sato S, Narita H, Abdelgelil NH, Inoue M, Culleton R, Kaneko O, Nakagawa A, Horii T, Akira S, Ishii KJ, Coban C.
    Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism.
    Cell Host Microbe.2012 Nov 15;12(5):705-16. doi: 10.1016/j.chom.2012.10.010.
  • Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H.
    Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors.
    Nat Commun.2012;3:1034. doi: 10.1038/ncomms2023.
  • Sato S, Kiyono H. (Review article)
    The mucosal immune system of the respiratory tract.
    Curr Opin Virol.2012 Jun;2(3):225-32. doi: 10.1016/j.coviro.2012.03.009.

2011以前

  • Kim DY, Sato A, Fukuyama S, Sagara H, Nagatake T, Kong IG, Goda K, Nochi T, Kunisawa J, Sato S, Yokota Y, Lee CH, Kiyono H.
    The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens.
    J Immunol. 2011 Apr 1;186(7):4253-62.
  • Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, Hanakawa Y, Dai X, Ishimatsu-Tsuji Y, Metzger D, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K.
    Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice.
    PLoS ONE. 2010;5(6): e11275.
  • Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, Shinzaki S, Fujihashi K, Sasakawa C, Iijima H, Goto M, Umesaki Y, Benno Y, Kiyono H.
    Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis.
    Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7419-24.
  • Halaas O, Steigedal M, Haug M, Awuh JA, Ryan L, Brech A, Sato S, Husebye H, Cangelosi GA, Akira S, Strong RK, Espevik T, Flo TH.
    Intracellular Mycobacterium avium Intersect Transferrin in the Rab11(+) Recycling Endocytic Pathway and Avoid Lipocalin 2 Trafficking to the Lysosomal Pathway.
    J Infect Dis. 2010 Mar 1;201(5):783-92.
  • Satoh T, Kato H, Kumagai Y, Yoneyama M, Sato S, Matsushita K, Tsujimura T, Fujita T, Akira S, Takeuchi O.
    LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
    Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7.
  • Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H.
    Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
    J Exp Med. 2009 Oct 26;206(11):2351-64.
  • Garcia M, Dogusan Z, Moore F, Sato S, Hartmann G, Eizirik DL, Rasschaert J.
    Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.
    Biochim Biophys Acta. 2009 Nov;1793(11):1768-75.
  • Abu-Dayyeh I, Shio MT, Sato S, Akira S, Cousineau B, Olivier M.
    Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif.
    PLoS Negl Trop Dis. 2008;2(12):e305.
  • Saiga H, Nishimura J, Kuwata H, Okuyama M, Matsumoto S, Sato S, Matsumoto M, Akira S, Yoshikai Y, Honda K, Yamamoto M, Takeda K.
    Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.
    J Immunol. 2008 Dec 15;181(12):8521-7.
  • Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S.
    Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
    Nat Immunol. 2008 Jul;9(7):769-76.
  • Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S.
    Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
    Nat Immunol. 2008 Jun;9(6):684-91.
  • Nishimura J, Saiga H, Sato S, Okuyama M, Kayama H, Kuwata H, Matsumoto S, Nishida T, Sawa Y, Akira S, Yoshikai Y, Yamamoto M, Takeda K.
    Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.
    J Immunol. 2008 Mar 15;180(6):4032-9.
  • Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
    Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
    J Exp Med. 2007 Sep 3;204(9):2233-9.
  • Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S.
    Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.
    J Exp Med. 2007 May 14;204(5):1013-24.
  • Gohda J, Irisawa M, Tanaka Y, Sato S, Ohtani K, Fujisawa JI, Inoue JI
    HTLV-1 Tax-induced NFkappaB activation is independent of Lys-63-linked-type polyubiquitination
    Biochem Biophys Res Commun. 2007 May 25;357(1):225-30.
  • Yao J, Kim T, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Wen Q, Gulen MF, Sizemore N, Didonato J, Sato S, Akira S, Su B, Li X.
    IL-1-induced TAK1- versus MEKK3-dependent NFkB activation pathways bifurcate at IRAK modification.
    J Biol Chem. 2007 Mar 2;282(9):6075-89.
  • Choo MK, Kawasaki N, Singhirunnusorn P, Koizumi K, Sato S, Akira S, Saiki I, Sakurai H.
    Blockade of transforming growth factor-beta-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade.
    Mol Cancer Ther. 2006 Dec;5(12):2970-6.
  • Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S.
    Pathological role of Toll-like receptor signaling in cerebral malaria.
    Int Immunol. 2007 Jan;19(1):67-79.
  • Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.
    Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling.
    J Immunol. 2006 Dec 1;177(11):7520-4.
  • Matsui K, Kumagai Y, Kato H, Sato S, Kawagoe T, Uematsu S, Takeuchi O, Akira S.
    Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
    J Immunol. 2006 Nov 1;177(9):5785-9.
  • Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S.
    TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
    Int Immunol. 2006 Oct;18(10):1405-11.
  • Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.
    Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
    Nat Immunol. 2006 Sep;7(9):962-70.
  • Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S.
    Essential role of IPS-1 in innate immune responses against RNA viruses.
    J Exp Med. 2006 Jul 10;203(7):1795-803.
  • Sayama K, Hanakawa Y, Nagai H, Shirakata Y, Dai X, Hirakawa S, Tokumaru S, Tohyama M, Yang L, Sato S, Akira S, Hashimoto K.
    TAK1 is essential for differentiation and the prevention of apoptosis in epidermis.
    J Biol Chem. 2006 Aug 4;281(31):22013-20.
  • Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X.
    TLR8-mediated NFkappa B and JNK activation are TAK1-independent and MEKK3-dependent.
    J Biol Chem. 2006 Jul 28;281(30):21013-21.
  • Takegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, Mizui M, Yamamoto M, Prasad DV, Suzuki K, Ishii M, Terai K, Moriya M, Nakatsuji Y, Sakoda S, Sato S, Akira S, Takeda K, Inui M, Takai T, Ikawa M, Okabe M, Kumanogoh A, Kikutani H.
    Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
    Nat Cell Biol. 2006 Jun;8(6):615-22.
  • Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, Ninomiya-Tsuji J.
    TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis.
    J Biol Chem. 2006 Jul 14;281(28):19610-7.
  • Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S.
    Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
    Nature. 2006 May 4;441(7089):101-5.
  • Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S.
    Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA.
    J Immunol. 2006 Apr 15;176(8):4520-4.
  • Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J.
    TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
    J Biol Chem. 2006 Mar 24;281(12):7863-72.
  • Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S.
    A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
    Nat Immunol. 2006 Jan;7(1):40-8.
  • Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.
    Essential function for the kinase TAK1 in innate and adaptive immune responses.
    Nat Immunol. 2005 Nov;6(11):1087-95.
  • Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S.
    IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Nat Immunol. 2005 Oct;6(10):981-8.
  • Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S.
    Cell type-specific involvement of RIG-I in antiviral response.
    Immunity. 2005 Jul;23(1):19-28.
  • Rasschaert J, Ladriere L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL.
    Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.
    J Biol Chem. 2005 Oct 7;280(40):33984-91.
  • Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S.
    Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
    J Exp Med. 2005 Mar 21;201(6):915-23.
  • Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S.
    Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
    J Exp Med. 2005 Jan 3;201(1):19-25.
  • Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A.
    Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
    Nature. 2004 Dec 16;432(7019):917-21.
  • Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue J, Uematsu S, Takeuchi O, Akira S.
    Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
    Nat Immunol. 2004 Oct;5(10):1061-8.
  • Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.
    Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
    Nature. 2004 Jul 8;430(6996):218-22.
  • Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.
    The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
    J Exp Med. 2004 Jun 21;199(12):1641-50.
  • Akira S, Sato S.
    Toll-like receptors and their signaling mechanisms.
    Scand J Infect Dis. 2003;35(9):555-62. Review.
  • Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.
    TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
    Nat Immunol. 2003 Nov;4(11):1144-50.
  • Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S.
    Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.
    J Immunol. 2003 Oct 15;171(8):4304-10.
  • Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.
    Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
    Science. 2003 Aug 1;301(5633):640-3.
  • *Yamamoto M, *Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S. (*equally contributed)
    Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
    J Immunol. 2002 Dec 15;169(12):6668-72.
  • Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.
    Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
    Nature. 2002 Nov 21;420(6913):324-9.
  • Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, Abe T, Seki E, Sato S, Takeuchi O, Takeda K, Akira S, Yamanishi K, Kawase I, Nakanishi K, Kishimoto T.
    SOCS-1 participates in negative regulation of LPS responses.
    Immunity. 2002 Nov;17(5):677-87.
  • Sato S, Takeuchi O, Fujita T, Tomizawa H, Takeda K, Akira S.
    A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways.
    Int Immunol. 2002 Jul;14(7):783-91.
  • Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S.
    Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
    J Immunol. 2002 Jul 1;169(1):10-4.
  • Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.
    Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
    Nat Immunol. 2002 Feb;3(2):196-200.
  • Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, Sato S, Hoshino K, Akira S.
    Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.
    J Immunol. 2001 Nov 15;167(10):5887-94.
  • Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S.
    A Toll-like receptor recognizes bacterial DNA.
    Nature. 2000 Dec 7;408(6813):740-5.
  • Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt PF, Takeda K, Akira S.
    Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways.
    J Immunol. 2000 Dec 15;165(12):7096-101.
  • Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, Akira S.
    Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.
    J Immunol. 2000 Apr 1;164(7):3476-9.
  • Murakami K, Sato S, Nagasawa S, Yamashita T.
    Regulation of mast cell signaling through high-affinity IgE receptor by CD45 protein tyrosine phosphatase.
    Int Immunol. 2000 Feb;12(2):169-76.