email: hiwaku@wakayama-med.ac.jp
Professor:Hiroshi Iwakura, MD, PhD
![顔写真](/pharm/yakuchi/image/Iwakuraface.gif)
College, Medical Degree:Faculty of Medicine, Kyoto University (1990-1996)
Residency:Kyoto University Hospital (1996-1997), Kitano Hospital, Osaka (1997-1999)
Graduate: Kyoto University Graduate School of Medicine (1999-2003)
Fellow: Department of Endocrinology and Metabolism, Kyoto University Hospital (2003-2004).
Assistant professor at Ghrelin Research Project, Translational Research Center, Kyoto UNiversity Hospital (2004-2011)
Associate professor at TK project, Medical Innovation Center, Kyoto University Graduate School of Medicine (2011-2015).
Lecurer at the first Department of Medicine, Wakayama Medical University (2015-2022).
Professor at Laboratory of Pharmacoterapeutics, School of Pharmacotherapeutics, Wakayama Medical University.
The Japanese Society of Internal Medicine
The Japan Diabetes Society
The Japan Endocrine Society (Councilor)
Japan Society for the Study of Obesity (JASSO)
Japan Thyroid Association
Awards
JES Research Award (2013)
JASSO Research ASward (2016)
Publications
Original Articles
Original articles
Ghrelin research
Kurimoto C, Furukawa Y, Akamizu T, Doi A, Takeshima K, Morita S, Iwakura H, Ariyasu H, Furuta H, Nishi M, Matsuoka TA.
Generation of a mouse model of thyroid storm and preliminary investigation of the therapeutic effects of ghrelin.
BMC Endocr Disord. 2024;24(1):150.
Kaneko K, Tokuyama Y, Taniguchi E, Abe S, Nakato J, Iwakura H, Sato M, Kurabayashi A, Suzuki H, Ito A, Higuchi Y, Nakayama R, Uchiyama K, Takahashi H, Ohinata K.
Rice Endoplasmic Protein-Derived Peptides, Rice-Ghretropins A and B, Stimulate Ghrelin Release in MGN3-1 Cells and Increase Plasma Acylated Ghrelin and Food Intake in Mice.
J Agric Food Chem.2023.71(1):421-429.
Hayakawa S, Tanaka T, Ogawa R, Ito S, Ueno S, Koyama H, Tomotaka O, Sagawa H, Tanaka T, Iwakura H, Takahashi H, Matsuo Y, Mitsui A, Kimura M, Takahashi S, Takiguchi S.
Potential Role of TRPV4 in Stretch-Induced Ghrelin Secretion and Obesity.
Int J Endocrinol. 2022. 2022: 7241275.
Tanikawa K, Kaneko K, Abe S, Nakato J, Tokuyama Y, Odaka S, Iwakura H, Sato M, Kurabayashi A, Suzuki H, Makita M, Ikemoto H, Matsumura S, Inoue K, Ohinata K.
Wheat-ghretropins: Novel ghrelin-releasing peptides derived from wheat protein.
FEBS Open Bio. 2021 Apr;11(4):1144-1152.
Godlewski G, Cinar R, Coffey NJ, Liu J, Jourdan T, Mukhopadhyay B, Chedester L, Liu Z, Osei-Hyiaman D, Iyer MR, Park JK, Smith RG, Iwakura H, Kunos G.
Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis.
Cell Metab. 2019 Jun 4;29(6):1320-1333.
Nakato J, Aoki H, Tokuyama Y, Yamamoto Y, Iwakura H, Matsumura S, Inoue K, Ohinata K.
Comprehensive analysis of a dipeptide library to identify ghrelin release-modulating peptides.
FEBS Lett. 2019 Sep;593(18):2637-2645.
Bando M, Iwakura H, Ueda Y, Ariyasu H, Inaba H, Furukawa Y, Furuta H, Nishi M, Akamizu T.
IL-1β directly suppress ghrelin mRNA expression in ghrelin-producing cells.
Mol Cell Endocrinol. 2017;447:45-51.
Tsuchiya T, Iwakura H, Minamino N, Kangawa K, Sasaki K
Endogenous peptide profile for elucidating biosynthetic processing of the ghrelin precursor.
Biochem Biophys Res Commun. 2017 Sep 2;490(4):1142-1146.
Nakato J, Aoki H, Iwakura H, Suzuki H, Kanamoto R, Ohinata K.
Soy-ghretropin, a novel ghrelin-releasing peptide derived from soy protein.
FEBS Lett. 2016 Aug;590(16):2681-9.
Aoki H, Nakato J, Mizushige T, Iwakura H, Sato M, Suzuki H, Kanamoto R, Ohinata K.
Lacto-ghrestatin, a novel bovine milk-derived peptide, suppresses ghrelin secretion.
FEBS Lett. 2017 Jul;591(14):2121-2130.
Bando M, Iwakura H, Koyama H, Hosoda H, Shigematsu Y, Ariyasu H, Akamizu T, Kangawa K, Nakao K.
High Incorporation of Long-Chain Fatty Acids Contributes to the Efficient Production of Acylated Ghrelin in Ghrelin-producing Cells.
FEBS Lett. 2016 Apr;590(7):992-1001.
Koyama H, Iwakura H, Dote K, Bando M, Hosoda H, Ariyasu H, Kusakabe T, Son C, Hosoda K, Akamizu T, Kangawa K, Nakao K.
Comprehensive Profiling of GPCR Expression in Ghrelin-producing Cells.
Endocrinology. 2016;157(2):692-704.
Mohan H, Ramesh N, Mortazavi S, Le A, Iwakura H, Unniappan S.
Nutrients Differentially Regulate Nucleobindin-2/Nesfatin-1 In Vitro in Cultured Stomach Ghrelinoma (MGN3-1) Cells and In Vivo in Male Mice.
PLoS One. 2014 Dec 15;9(12):e115102.
Ariyasu H, Yamada G, Iwakura H, Matsumura S, Inoue K, Kangawa K, Nakao K, Akamizu T.
Reduction in circulating ghrelin concentration after maturation does not affect food intake.
Endocr J. 2014;61(10):1041-52.
Ariyasu H, Iwakura H, Yukawa N, Murayama T, Yokode M, Tada H, Yoshimura K, Teramukai S, Ito T, Shimizu A, Yonezawa A, Kangawa K, Mimori T, Akamizu T.
Clinical effects of ghrelin on gastrointestinal involvement in patients with systemic sclerosis.
Endocr J. 2014;61(7):735-42.
Karra E, O'Daly OG, Choudhury AI, Yousseif A, Millership S, Neary MT, Scott WR, Chandarana K, Manning S, Hess ME, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew ME, Rahman S, Emmanuel JJ, Williams SC, Rüther UU, Brüning JC, Withers DJ, Zelaya FO, Batterham RL.
A link between FTO, ghrelin, and impaired brain food-cue responsivity.
J Clin Invest. 2013 Aug 1;123(8):3539-51.
Bando M, Iwakura H, Ariyasu H, Koyama H, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T.
Overexpression of intraislet ghrelin enhances β-cell proliferation after streptozotocin-induced β-cell injury in mice.
Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E140-8.
Ariyasu H, Yamada G, Iwakura H, Akamizu T, Kangawa K, Nakao K.
Transgenic mice overexpressing ghrelin or ghrelin analog.[Review]
Methods Enzymol. 2012;514:371-7.
Janssen S, Laermans J, Iwakura H, Tack J, Depoortere I.
Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein.
PLoS One. 2012;7(6):e40168.
Bando M, Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T.
Transgenic overexpression of intra-islet ghrelin does not affect insulin secretion or glucose metabolism in vivo.
Am J Physiol Endocrinol Metab. 2012;302(4):E403-8.
Akamizu T, Sakura N, Shigematsu Y, Tajima G, Ohtake A, Hosoda H, Iwakura H, Ariyasu H, Kangawa K.
Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II.
Eur J Endocrinol. 2012 Feb;166(2):235-40.
Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
Oxytocin and dopamine stimulate ghrelin secretion by the ghrelin-producing cell line, MGN3-1 in vitro.
Endocrinology. 2011 Jul;152(7):2619-25.
Yamada G, Ariyasu H, Iwakura H, Hosoda H, Akamizu T, Nakao K, Kangawa K.
Generation of Transgenic Mice Over-expressing a Ghrelin Analog.
Endocrinology 2010 Dec;151(12):5935-40.
Iwakura H, Li Y, Ariyasu H, Hosoda H, Kanamoto N, Bando M, Yamada G, Hosoda K, Nakao K, Kangawa K, Akamizu T.
Establishment of a Novel Ghrelin-Producing Cell Line.
Endocrinology. 2010;151(6):2940-5.
Ariyasu H, Iwakura H, Yamada G, Kanamoto N, Bando M, Kohno K, Sato T, Kojima M, Nakao K, Kangawa K, Akamizu T.
A postweaning reduction in circulating ghrelin temporarily alters growth hormone (GH) responsiveness to GH-releasing hormone in male mice but does not affect somatic growth.
Endocrinology. 2010 Apr;151(4):1743-50.
Iwakura H, Ariyasu H, Li Y, Kanamoto N, Bando M, Yamada G, Hosoda H, Hosoda K, Shimatsu A, Nakao K, Kangawa K, Akamizu T.
A mouse model of ghrelinoma exhibited activated growth hormone-insulin-like growth factor I axis and glucose intolerance.
Am J Physiol Endocrinol Metab. 2009;297(3):E802-11.
Akamizu T, Iwakura H, Ariyasu H, Murayama T, Sumi E, Teramukai S, Goto K, Ohnishi E, Akiyama H, Kawanabe K, Nankaku M, Ichihashi N, Tsuboyama T, Tamai K, Kataoka M, Nakamura T, Kangawa K, for the OA-THR Clinical Study Team.
Effects of ghrelin treatment in patients undergoing total hip replacement for osteoarthritis: Different outcomes from studies in patients with cardiac and pulmonary cachexia.
J Am Geriatr Soc 2008;56(12):2363-5.
Ariyasu H, Iwakura H, Yamada G, Nakao K, Kangawa K, Akamizu T.
Efficacy of Ghrelin as a therapeutic approach for age-related physiologic changes.
Endocrinology. 2008 Mar 27 Jul;149(7):3722-8.
Akamizu T, Iwakura H, Ariyasu H, Hosoda H, Murayama T, Yokode M, Teramukai S, Seno H, Chiba T, Noma S, Nakai Y, Fukunaga M, Nakai Y, Kangawa K, FD Clinical Study Team.
Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite
Eur J Endocrinol. 2008 Apr;158(4):491-8.
Iwakura H, Akamizu T, Ariyasu H, Irako T, Hosoda K, Nakao K, Kangawa K.
Effects of ghrelin administration on decreased growth hormone status in obese animals.
Am J Physiol Endocrinol Metab. 2007;293(3):E819-25.
Irako T, Akamizu T, Hosoda H, Iwakura H, Ariyasu H, Tojo K, Tajima N, Kangawa K.
Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats.
Diabetologia. 2006 Jun;49(6):1264-73.
Akamizu T, Murayama T, Teramukai S, Miura K, Bando I, Irako T, Iwakura H, Ariyasu H, Hosoda H, Tada H, Matsuyama A, Kojima S, Wada T, Wakatsuki Y, Matsubayashi K, Kawakita T, Shimizu A, Fukushima M, Yokode M, Kangawa K.
Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure.
J Endocrinol. 2006 Feb;188(2):333-44.
Iwakura H, Hosoda K, Son C, Fujikura J, Tomita T, Noguchi M, Ariyasu H, Takaya K, Masuzaki H, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Itoh H, Toyokuni S, Kangawa K, Nakao K.
Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice.
J Biol Chem. 2005;280(15):15247-56.
Ariyasu H, Takaya K, Iwakura H, Hosoda H, Akamizu T, Arai Y, Kangawa K, Nakao K.
Transgenic Mice Overexpressing Des-acyl Ghrelin Show Small Phenotype.
Endocrinology 2005 Jan;146(1):355-64.
Iwakura H, Hosoda K, Doi R, Komoto I, Nishimura H, Son C, Fujikura J, Tomita T, Takaya K, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Kangawa K, Imamura M, Nakao K.
Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I.
J Clin Endocrinol Metab. 2002;87(11):4885-8.
GPR142 research
Ueda Y, Iwakura H, Bando M, Doi A, Ariyasu H, Inaba H, Morita S, Akamizu T.
Differential role of GPR142 in tryptophan-mediated enhancement of insulin secretion in obese and lean mice.
PLoS One. 2018;13(6):e0198762.
Obesity research
Fukuda N, Ojima T, Hayata K, Katsuda M, Kitadani J, Takeuchi A, Goda T, Ueda Y, Iwakura H, Nishi M, Yamaue H.
Laparoscopic sleeve gastrectomy for morbid obesity improves gut microbiota balance, increases colonic mucosal-associated invariant T cells and decreases circulating regulatory T cells.
Surg Endosc. 2022 Oct;36(10):7312-7324.
Guo T, Tanaka T, Matsumoto M, Kaneko K, Unzai T, Ogino Y, Aotani D, Kusakabe T, Iwakura H, Miyazawa T, Sawamoto K, Minokoshi Y, Masuzaki H, Inagaki N, Nakao K.
A combination of dietary fat intake and nicotine exposure enhances CB1 endocannabinoid receptor expression in hypothalamic nuclei in male mice.
Neurosci Lett. 2020 Jan 1;714:134550.
Izumi R, Kusakabe T, Noguchi M, Iwakura H, Tanaka T, Miyazawa T, Aotani D, Hosoda K, Kangawa K, Nakao K.
CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats.
J Lipid Res. 2018 Sep;59(9):1575-1585.
Iwakura H, Dote K, Bando M, Koyama H, Hosoda K, Kangawa K, Nakao K.
Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus.
PLoS One 2016;11(2):e0148639.
Noguchi M, Hosoda K, Fujikura J, Fujimoto M, Iwakura H, Tomita T, Ishii T, Arai N, Hirata M, Ebihara K, Masuzaki H, Itoh H, Narumiya S, Nakao K.
Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.
J Biol Chem. 2007 Oct 5;282(40):29574-83.
Son C, Hosoda K, Matsuda J, Fujikura J, Yonemitsu S, Iwakura H, Masuzaki H, Ogawa Y, Hayashi T, Itoh H, Nishimura H, Inoue G, Yoshimasa Y, Yamori Y, Nakao K.
Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes.
Endocrinology. 2001 Oct;142(10):4189-94.
Diabetes research
Ishibashi T, Morita S, Kishimoto S, Uraki S, Takeshima K, Furukawa Y, Inaba H, Ariyasu H, Iwakura H, Furuta H, Nishi M, Papa FR, Akamizu T.
nAChR signaling regulates IRE1α activation to protect β cells against terminal unfolded protein response under irremediable ER stress.
J Diabetes Investig. 2020 Jan 10;11(4):801-813.
Matsutani N, Furuta H, Matsuno S, Oku Y, Morita S, Uraki S, Doi A, Furuta M, Iwakura H, Ariyasu H, Nishi M, Akamizu T.
Identification of a compound heterozygous inactivating ABCC8 gene mutation responsible for young-onset diabetes with exome-sequencing.
J Diabetes Investig. 2020 Mar;11(2):333-336.
Uraki S, Furuta H, Miyawaki M, Matsutani N, Shima Y, Iwamoto M, Matsuno S, Morita S, Furuta M, Doi A, Iwakura H, Ariyasu H, Nishi M, Suzuki H, Akamizu T.
Neonatal diabetes caused by the heterozygous Pro1198Leu mutation in the ABCC8 gene in a male infant: six-year clinical course.
J Diabetes Investig. 2020 Mar;11(2):502-505.
Matsuno S, Furuta H, Kosaka K, Doi A, Yorifuji T, Fukuda T, Senmaru T, Uraki S, Matsutani N, Furuta M, Mishima H, Iwakura H, Nishi M, Yoshiura K, Fukui M, Akamizu T.
Identification of a variant associated with early-onset diabetes in the intron of the insulin gene with exome sequencing.
J Diabetes Investig. 2019 Jul;10(4):947-950.
Fujikura J, Hosoda K, Kawaguchi Y, Noguchi M, Iwakura H, Odori S, Mori E, Tomita T, Hirata M, Ebihara K, Masuzaki H, Fukuda A, Furuyama K, Tanigaki K, Yabe D, Nakao K.
Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development.
Dev Dyn. 2007 Oct;236(10):2779-91.
Tomita T, Masuzaki H, Iwakura H, Fujikura J, Noguchi M, Tanaka T, Ebihara K, Kawamura J, Komoto I, Kawaguchi Y, Fujimoto K, Doi R, Shimada Y, Hosoda K, Imamura M, Nakao K.
Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumors in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.
Diabetologia. 2006 May;49(5):962-8.
Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K.
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
Cell Metab. 2006;3(1):59-65.
Tomita T, Masuzaki H, Noguchi M, Iwakura H, Fujikura J, Tanaka T, Ebihara K, Kawamura J, Komoto I, Kawaguchi Y, Fujimoto K, Doi R, Shimada Y, Hosoda K, Imamura M, Nakao K.
GPR40 gene expression in human pancreas and insulinoma.
Biochem Biophys Res Commun. 2005 Dec 30;338(4):1788-90.
Thyroid research
Iwakura H, Takagi T, Inaba H, Doi A, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Ishibashi T, Morita S, Matsuno S, Nishi M, Furuta H, Matsuoka T, Akamizu T.
Thyroid function, glycemic control, and diabetic nephropathy in patients with type 2 diabetes over 24 months: prospective observational study
BMC Endocrine Disorders.2023;23(1):146.
Inaba H, Ariyasu H, Iwakura H, Kurimoto C, Takeshima K, Morita S, Furuta H, Hotomi M, Akamizu T.
Distinct clinical features and prognosis between persistent and temporary thyroid dysfunctions by immune-checkpoint inhibitors.
Endocr J. 2021 Feb 28;68(2):231-241.
Inagaki Y, Takeshima K, Nishi M, Ariyasu H, Doi A, Kurimoto C, Uraki S, Morita S, Furukawa Y, Inaba H, Iwakura H, Shimokawa T, Utsunomiya T, Akamizu T.
The influence of thyroid autoimmunity on pregnancy outcome in infertile women: a prospective study.
Endocr J. 2020 Aug 28;67(8):859-868.
Kurimoto C, Inaba H, Ariyasu H, Iwakura H, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Morita S, Yamamoto Y, Yamashita S, Katsuda M, Hayata A, Akamatsu H, Jinnin M, Hara I, Yamaue H, Akamizu T.
Predictive and sensitive biomarkers for thyroid dysfunctions during treatment with immune-checkpoint inhibitors.
Cancer Sci. 2020 May;111(5):1468-1477.
Inaba H, Ariyasu H, Takeshima K, Iwakura H, Akamizu T.
Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases.
Endocr J. 2019 Oct 28;66(10):843-852.
Neuroblastoma Research
Hadjidaniel MD, Muthugounder S, Hung LT, Sheard MA, Shirinbak S, Chan RY, Nakata R, Borriello L, Malvar J, Kennedy RJ, Iwakura H, Akamizu T, Sposto R, Shimada H, DeClerck YA, Asgharzadeh S.
Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.
Oncotarget. 2017 Sep 16;8(53):91516-91529.
Kawano K, Hattori Y, Iwakura H, Akamizu T, Maitani Y.
Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma.
Cancer Med. 2013 Jun;2(3):286-95.
Kawano K, Hattori Y, Iwakura H, Akamizu T, Maitani Y.
Adrenal tumor volume in a genetically engineered mouse model of neuroblastoma determined by magnetic resonance imaging.
Exp Ther Med. 2012 Jul;4(1):61-64.
Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Nakao K, Maitani Y.
Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma..
Int J Oncol. 2010 Sep;37(3):695-705.
Iwakura H, Ariyasu H, Kanamoto N, Hosoda K, Nakao K, Kangawa K, Akamizu T.
Establishment of a novel neuroblastoma mouse model.
Int J Oncol 2008;33(6):1195-9
CNP研究
Ensho T, Hino J, Ueda Y, Miyazato M, Iwakura H.
Vascular endothelial cell-specific overexpression of CNP did not improve liver fibrosis in HFFCD-induced NASH, but did improve renal lesions.
Peptides.2024
Endocrinology research
Inaba H, Ariyasu H, Iwakura H, Ueda Y, Kurimoto C, Uraki S, Takeshima K, Yamaoka H, Furukawa Y, Morita S, Nishi M, Akamizu T.
Comparative analysis of HLA between Idiopathic and Anti-PD-1 antibody induced Isolated ACTH deficiency: A Pilot Study.
Clin Endocrinol (Oxf). 2019 Dec91(6):786-792
Kawai S, Ariyasu H, Uraki S, Takeshima K, Morita S, Inaba H, Iwakura H, Doi A, Ohashi T, Kawago M, Matsuoka N, Okamura S, Tsujii S, Akamizu T.
Imbalanced Expression of IGF2 and PCSK4 Is Associated With Overproduction of Big IGF2 in SFT With NICTH: A Pilot Study.
J Clin Endocrinol Metab. 2018 Jul 1;103(7):2728-2734.
Case reports
Kishimoto S, Morita S, Kurimoto C, Kitahara C, Tsuji T, Uraki S, Takeshima K, Furukawa Y, Iwakura H, Furuta H, Nishi M, Matsuoka TA.
Hypopituitarism and cranial nerve involvement mimicking Tolosa-Hunt syndrome as the initially presenting feature of diffuse large B-cell lymphoma: a case report.
BMC Endocr Disord. 2022 Mar 14;22(1):65.
Nishi N, Takeshima K, Morita S, Iwakura H, Nishi M, Matsuoka T
Deterioration of pituitary function without relapse after steroid therapy for IgG4-related hypophysitis.
Endocrinol Diabetes Metab Case Rep. 2021 Jul 1;2021:21-0029.
Kitahara C, Morita S, Kishimoto S, Matsuno S, Uraki S, Takeshima K, Furukawa Y, Inaba H, Iwakura H, Ariyasu H, Furuta H, Nishi M, Akamizu T.
Early detection of euglycemic ketoacidosis during thoracic surgery associated with empagliflozin in a patient with type 2 diabetes: A case report
J Diabetes Investig. 2021 Apr;12(4):664-667.
Tsuji T, Hiroyuki A, Uraki S, Doi A, Morita S, Iwakura H, Nishi M, Furuta H, Akamizu T.
Autosomal Dominant Hypocalcemia With Atypical Urine Findings Accompanied by Novel CaSR Gene Mutation and VitD Deficiency.
J Endocr Soc. 2020 Dec 4;5(3):bvaa190.
Nakao T, Takeshima K, Ariyasu H, Kurimoto C, Uraki S, Morita S, Furukawa Y, Iwakura H, Akamizu T.
Thyroid storm with delayed hyperbilirubinemia and severe heart failure: indication and contraindication of plasma exchange.
Endocrinol Diabetes Metab Case Rep. 2020 Sep 4;2020:20-0036
Takeshima K, Ariyasu H, Uraki S, Morita S, Furukawa Y, Inaba H, Iwakura H, Doi A, Warigaya K, Murata SI, Enomoto K, Hotomi M, Akamizu T.
False-positive staining of thyroglobulin distinguished from mixed medullary and follicular thyroid carcinoma by duplex in situ hybridization.
Endocr J. 2020 Oct 28;67(10):1007-1017.
Morita S, Takeshima K, Ariyasu H, Furukawa Y, Kishimoto S, Tsuji T, Uraki S, Mishima H, Kinoshita A, Takahashi Y, Inaba H, Iwakura H, Furuta H, Nishi M, Doi A, Murata SI, Yoshiura KI, Akamizu T.
Expression of unfolded protein response markers in the pheochromocytoma with Waardenburg syndrome: a case report.
BMC Endocr Disord. 2020 Jun 22;20(1):90.
Inaba H, Ariyasu H, Iwakura H, Kurimoto C, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Morita S, Nakayama Y, Ohashi T, Ito H, Nishimura Y, Akamizu T.
Autoimmune polyglandular syndrome type 2 and autoimmune hepatitis with thymoma-associated myasthenia gravis: case report.
BMC Endocr Disord. 2020 Apr 7;20(1):47.
Takeshima K, Ariyasu H, Uraki S, Kitahara C, Morita S, Inaba H, Iwakura H, Warigaya K, Murata SI, Yamazaki Y, Sasano H, Akamizu T
Head and Neck Paraganglioma Atypically Carrying a Succinate Dehydrogenase Subunit B Mutation (L157X).
Intern Med. 2020 May 1;59(9):1167-1171.
Karatojima M, Furuta H, Matsutani N, Matsuno S, Tamai M, Komiya K, Morita S, Uraki S, Doi A, Furuta M, Iwakura H, Ariyasu H, Nishi M, Akamizu T.
A family in which people with a heterozygous ABCC8 gene mutation (p.Lys1385Gln) have progressed from hyperinsulinemic hypoglycemia to hyperglycemia.
J Diabetes. 2020 Jan;12(1):21-24.
Takeshima K, Ariyasu H, Iwakura H, Kawai S, Uraki S, Inaba H, Furuta M, Warigaya K, Murata SI, Akamizu T.
Predominant Improvement of Alpha Cell Function after Steroid Therapy in a Patient with Autoimmune Pancreatitis: Case Report.
Diabetes Ther. 2018 Jun;9(3):1385-1395.
Shiba M, Inaba H, Ariyasu H, Kawai S, Inagaki Y, Matsuno S, Iwakura H, Yamamoto Y, Nishi M, Akamizu T.
A Case of Fulminant Type 1 Diabetes Mellitus Accompanied by Positive Conversion of Anti-insulin Antibody after the Administration of Anti-CTLA-4 Antibody Following the Discontinuation of Anti-PD-1 Antibody.
Intern Med. 2018 Jul 15; 57(14): 2029–2034.
Ariyasu H, Inaba H, Ota T, Yamaoka H, Furukawa Y, Iwakura H, Doi N, Yamamoto Y, Akamizu T.
Thyrotoxicosis and Adrenocortical Hormone Deficiency During Immune-checkpoint Inhibitor Treatment for Malignant Melanoma.
In Vivo. 2018 Mar-Apr;32(2):345-351.
Ueda Y, Uraki S, Inaba H, Nakashima S, Ariyasu H, Iwakura H, Ota T, Furuta H, Nishi M, Akamizu T.
Graves' Disease in Pediatric and Elderly Patients with 22q11.2 Deletion Syndrome.
Intern Med. 2017;56(10):1169-1173.
Inaba H, Funahashi T, Ariyasu H, Iwakura H, Furuta H, Nishi M, Akamizu T.
Diabetic ketoacidosis in a patient with acromegaly and central diabetes insipidus treated with octreotide long-acting release.
Diabetology International. 2017. 8(2):237-242.
Yagita M, Iwakura H, Kishimoto T, Okamura T, Kunitomi A, Tabata R, Konaka Y, Kawa K.
Successful allogeneic stem cell transplantation from an unrelated donor for aggressive Epstein-Barr virus-associated clonal T-cell proliferation with hemophagocytosis.
Int J Hematol. 2001 Dec;74(4):451-4.
Reviews
Iwakura H, Ensho T, Ueda Y.
Desacyl-ghrelin, not just an inactive form of ghrelin?-A review of current knowledge on the biological actions of desacyl-ghrelin.[Review]
Peptides.2023.Online ahead of print.
Inaba H, Ariyasu H, Takeshima K, Iwakura H, Akamizu T.
Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases. [Review].
Endocr J. 2019;66(10):843-852.
Iwakura H, Kangawa K, Nakao K.
The regulation of circulating ghrelin - with recent updates from cell-based assays [Review].
Endocr J. 2015;62(2):107-22.
Akamizu T, Iwakura H, Ariyasu H, Kangawa K.
Ghrelin and functional dyspepsia.
Int J Pept. 2010;2010. pii: 548457.
Books
Iwakura H, Akamizu T
Neuroblastoma (Pediatric Cancer), p31, Neuroblastoma mouse model, Springer, 2011
Proceedings
Iwakura H, Bando M, Ueda Y, Akamizu T
The effects of inflammatory cytokines on the expression of ghrelin. [Proceedings]
Endocr J. 2017;64 (Suppl.):S25-S26.