In 2025

• Sasaki H, Otake K, Takeda K, Tesaki K, Takahashi E, Yasuda J, Matsuda S, Kawasaki A, Watanabe M, Otani K, Okada M, Sekijima M, Yamawaki H, Sasaki N.
  Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury
  PLOS ONE, 20(5): e0323428, 2025
• Katsuya Kami , Fumihiro Tajima, Kohei Minami, Takuma Kami, Shogo Habata, Takuya Notomi, Ken Kouda, Tomoe Nishitani, Emiko Senba. Exercise–induced hypoalgesia: Mechanisms and barriers.
  Pain Res, 40: 65-73, 2025

In 2024

• Natalie Samper, Lilja Hardardottir, Delphine M Depierreux, Soomin C Song, Ayano Nakazawa, Ivan Gando, Tomoe Y Nakamura, Andrew M Sharkey, Carla R Nowosad, Stefan Feske, Francesco Colucci, William A Coetzee.
  Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development.
  Front Immunol. 15: 1490250, 2024
• Eylem Taskin, Natalie Samper, Hua-Qian Yang, Tomoe Y Nakamura,
  Ravichandran Ramasamy, William Coetzee
  Archives of Pharmacy 74 (Notebook 5), 625-657
  KATP channels and cardioprotection
• Liu C, Chen IS, Barri M, Murrell-Lagnado R, Kubo Y.
  Structural determinants of M2R involved in inhibition by Sigma-1R.
  J Biol Chem, 300(12):108006, 2024.
• Matsumura S#, Yasuda J#, Notomi T, Suzuki Y, Chen IS, Murakami D, Hotomi M, Nakamura TY*.
  Direct toxicity of cigarette smoke extract on cardiac function mediated by mitochondrial dysfunction in Sprague-Dawley rat ventricular myocytes and human induced pluripotent stem cell-derived cardiomyocytes.
  PLoS One, 19(1): e0295737, 2024.
• Chen IS*, Yasuda J, Notomi T, Nakamura TY*.
  Licorice metabolite 18β-glycyrrhetinic acid activates G protein-gated inwardly rectifying K+ channels.
  Br J Pharmacol, 181(3):447-463, 2024.
• Liu C, Chen IS, Tateyama M, Kubo Y.
  Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist.
  J Biol Chem, 300(5):107219, 2024.

In 2023

• Gando I, Becerra Flores M, Chen IS, Yang HQ, Nakamura TY, Cardozo TJ, Coetzee WA.
  CL-705G: a novel chemical Kir6.2-specific KATP channel opener Front Pharmacol, 20;14:1197257, 2023.
• Mao D, Inoue H, Notomi T*, Goda S*.
  P38α contributes to TNF-α-induced IL-8 production in human gingival cells.Biofactors, 49(6):1223-1232, 2023.

In 2022

• Chen IS*, Eldstrom J, Fedida D, Kubo Y.
  A novel ion conducting route besides the central pore in an inherited mutant of G‐protein‐gated inwardly rectifying K+ channel.J Physiol, 600(3):603-622, 2022.

In 2021

• Notomi T*, Kobayashi R, Otsuka M, Kise C, Momota Y, Ezura Y, Kawazoe T.
  Light-induced Membrane Hyperpolarization Promotes Osteoblast Differentiation in MC3T3 Osteoblast-like Cells.
  J Hard Tissue Biol, 30: 4: 347-354, 2021
• Notomi T*, Kise C, Kobayashi R, Otsuka M, Momota Y, Ezura Y, Kawazoe T.
  TPC1 and TPC2 Promote Osteoclastogenesis.
  J Hard Tissue Biol, 30: 4: 333-338, 2021
• Notomi T*, Otsuka M, Kise C, Kobayashi R, Momota Y and Kawazoe T.
  Delivery of plasmid DNA into pre-osteoclast-like and mature osteoclast-like cells using cationic peptides.
  J Osaka Dent Univ, 55: 2: 239-243, 2021
• 中村(西谷)友重*
  小児特有の心筋細胞内Ca2+シグナル調節機構とその治療標的としての可能性
  日本薬理学会誌, 2021: 156(6);346-350
• 西谷(中村)友重*
  興奮性細胞における新規Ca2+シグナル制御因子NCS-1の多彩な生理機能と各種疾患との関連
  和歌山医学, 2021;72(4);192-197
• Kiguchi N*, Fukazawa Y, Saika A, Uta D, Saika F, Nakamura TY, Ko MC, Kishioka S.
  Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.
  Pharmacology research ＆ perspectives, 2021; 9; e00790
• Saika F, Matsuzaki S, Kishioka S, Kiguchi N.
  Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice Cells, 2021; 10; 874
• Matsuki Y, Yanagawa T, Sumiyoshi H, Yasuda J, Nakao S, Goto M, Shibata-Seki T, Akaike T, Inagaki Y.
  Modification of exosomes with carbonate apatite and a glycan polymer improves transduction efficiency and target cell selectivity.
  Bioche Biophys Res Commun. 2021; 583 93-99
• Sumiyoshi H, Okamura Y, Kawaguchi T A, Kubota T, Endo H, Yanagawa T, Yasuda J, Matsuki Y, Nakao S, Inagaki Y.
  External administration of moon jellyfish collagen solution accelerates physiological wound healing and improves delayed wound closure in diabetic model mice.
  Regenerative Therapy, 2021; 18 223-230

In 2020

• Kiguchi N*, Ding H, Ko MC.
  Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.
  J Neurosci Res. 2020 Apr 7. [Epub ahead of print] Review. PMID: 32255240
• Kiguchi N*,#, Uta D#, Ding H, Uchida H, Saika F, Matsuzaki S, Fukazawa Y, Abe M, Sakimura K, Ko MC, Kishioka S.
  Neuropharmacology. 2020 Mar 3;170:108025. PMID: 32142790
• Kobayashi D*, Kiguchi N, Saika F, Kishioka S, Matsuzaki S*.
  Insufficient efferocytosis by M2-like macrophages as a possible mechanism of neuropathic pain induced by nerve injury.
  Biochem Biophys Res Commun. 2020 Feb 19. [Epub ahead of print] PMID: 32087968
• 陳以珊*, 久保義弘.
  GIRKチャンネルの、小分子による新規機能調節機構.
  心電図 2020; 40(2);107-113.

In 2019

• Nakamura TY*, Nakao S, Wakabayashi S.
  Emerging Roles of neuronal Ca2+ Sensor-1 in Cardiac and neuronal Tissues：A Mini Review Front. Mol. Neurosci. 2019 12:56.
• Kiguchi N, Ko MC*.
  Effects of NOP-Related Ligands in Nonhuman Primates.
  Handb Exp Pharmacol. 2019;254:323-343. PMID: 30879202
• Kiguchi N#, Ding H#, Cami-Kobeci G, Sukhtankar DD, Czoty PW, DeLoid HB, Hsu FC, Toll L, Husbands SM*, Ko MC*.
  BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
  Br J Anaesth. 2019 Jun;122(6):e146-e156. PMID: 30916003
• Saika F, Kiguchi N*, Matsuzaki S, Kobayashi D, Kishioka S.
  Inflammatory macrophages in the sciatic nerves facilitate neuropathic pain associated with type 2 diabetes mellitus.
  J Pharmacol Exp Ther. 2019 Mar;368(3):535-544. PMID: 30602591
• Chen IS*, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y.
  Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.
  Br J Pharmacol. 2019; 176(17):3161-3179.
• Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack J, Kurachi Y.
  Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations.
  J Gen Physiol. 2019; 151(2):214-230.
• Ishii J, Suzuki A, Kimura T, Tateyama M, Tanaka T, Yazawa T, Arimasu Y, Chen IS, Aoyama K, Kubo Y, Saitoh S, Mizuno H, Kamma H.
  Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7.
  Commun Biol. 2019; 2:270.
• Yasuda J, Okada M, Yamawaki H.
  Protective effects of T3 peptide, an active fragment of tumstatin, against ischemia/reperfusion injury in rat heart.
  J. Pharmacol. Sci. 139: 193-200, 2019.
• Notomi T*, Hiyama A, Nozaki T.
  Establishment of RANKL-highly sensitive RAW264 subclones in accordance with high expression of TPC2.
  J Transl Sci, 6, 2019. doi: 10.15761/JTS.1000357 (4 pages).
• Notomi T*, Hiyama A, Nozaki T.
  Role of zinc and zinc-modulated ion channels, ORAI1 and HCN in osteoclasts.
  J Transl Sci, 6, 2019. doi: 10.15761/JTS.1000359 (4 pages)
• Inubushi M, Notomi T*, Nozaki T. Retinoic acid promotes migration of MC3T3-E1 osteoblast-like cells via RARα signaling-mediated upregulation of profilin-1 expression.
  J Osaka Dent Univ, 53: 2: 149-156, 2019.
• Notomi T*, Inubushi M, Nozaki T.
  Synaptotagmin VII RANKL-lysosomal vesicle fusion to the cell membrane in osteoblast-like cells.
  J Osaka Dent Univ, 53: 2: 141-147, 2019.

In 2018

• Kiguchi N*, Matsuzaki S, Saika F, Kobayashi D, Kishioka S.
  Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain.
  In: Epigenetics of Chronic Pain. Translational Epigenetics, 2018; 7: p49-68.
• Saika F, Matsuzaki S, Kobayashi D, Kiguchi N*, Kishioka S.
  Chemokine CXCL1 is responsible for cocaine-induced reward in mice.
  Neuropsychopharmacol Rep. 2018 Sep;38(3):145-148. PMID: 30175527.
• Ding H#, Kiguchi N#, Yasuda D, Daga PR, Polgar WE, Lu JJ, Czoty PW, Kishioka S, Zaveri NT*, Ko MC*.
  A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
  Sci Transl Med. 2018 Aug 29;10(456). pii: eaar3483. PMID: 30158150.
• Ding H#, Kiguchi N*,#, Kishioka S, Ma T, Peters CM, Ko MC. Differential mRNAexpression of neuroinflammatory modulators in the spinal cord and thalamus oftype 2 diabetic monkeys.
  J Diabetes. 2018 Nov;10(11):886-895. PMID: 29749036.
• Kiguchi N*, Kobayashi D, Saika F, Matsuzaki S, Kishioka S. Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury.
  J Neuroinflammation. 2018 Mar 27;15(1):96. PMID: 29587798.
• Saika F, Kiguchi N*, Wakida N, Kobayashi D, Fukazawa Y, Matsuzaki S, Kishioka S.
  Upregulation of CCL7 and CCL2 in reward system mediated through dopamine D1 receptor signaling underlies methamphetamine-induced place preference in mice.
  Neurosci Lett. 2018 Feb 5;665:33-37. PMID: 29174638.
• Chen IS* and Kubo Y.
  Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.
  J Physiol. 2018; 596(10):1833-1845.

In 2017

• Nakamura TY*, Nakao S, Nakajo Y, Takahashi JC, Wakabayashi S, Yanamoto H:
  Possible Signaling Pathways Mediating Neuronal Calcium Sensor-1-Dependent Spatial Learning and Memory in Mice. PLoS ONE, 2017 12(1) e0170829.
• Kiguchi N*, Kobayashi D, Saika F, Matsuzaki S, Kishioka S.
  Pharmacological Regulation of Neuropathic Pain Driven by Inflammatory Macrophages.
  Int J Mol Sci. 2017 Nov 1;18(11). pii: E2296. Review. PMID: 29104252.
• Kiguchi N*, Sakaguchi H, Kadowaki Y, Saika F, Fukazawa Y, Matsuzaki S, Kishioka S.
  Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.
  J Pharmacol Sci. 2017 Jan;133(1):53-56. PMID: 28057412.
• Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC*.
  Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.
  Biochim Biophys Acta. 2017 Jan;1863(1):274-283. PMID: 27751964.
• Chen IS*, Tateyama M, Fukata Y, Uesugi M, Kubo Y.
  Ivermectin activates GIRK channels in a PIP2-dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation.
  J Physiol. 2017; 595(17):5895-5912.
• Chen IS, Furutani K, Kurachi Y.
  Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity.
  Sci Rep. 2017; 7(1):6110.
• Tsukamoto H, Chen IS, Kubo Y, Furutani Y.
  A ciliary opsin in the brain of a marine annelid zooplankton is ultraviolet-sensitive, and the sensitivity is tuned by a single amino acid residue.
  J Bio Chem. 2017; 292(31):12971-12980.
• Yasuda J, Fukui K, Okada M, Yamawaki H.
  T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway.
  Naunyn-Schmiedeberg's Arch. Pharmacol. 390: 1135-1144, 2017.
• Yasuda J, Okada M, Yamawaki H.
  T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts.
  Eur. J. Pharmacol. 807: 64-70, 2017.
• Okada M, Imoto K, Sugiyama A, Yasuda J, Yamawaki H.
  New Insights into the Role of Basement Membrane-Derived Matricryptins in the Heart.Biol. Pharm. Bull. 40: 2050-2060, 2017.
• Notomi T*, Kuno M, Hiyama A, Nozaki T, Ohura K, Ezura Y, Noda M.
  Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions.
  J Biol Chem, 292: 12: 20998-21010, 2017.

In 2016

• Nakamura TY*, Nakao S, Wakabayashi S.
  Neuronal Ca2+ sensor-1 contributes to stress tolerance in cardiomyocytes via activation of mitochondrial detoxification pathways.
  J. Mol Cell Cardiol. 2016 99:23-34.
• Ding H, Czoty PW, Kiguchi N, Cami-Kobeci G, Sukhtankar DD, Nader MA, Husbands SM, Ko MC*.
  A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.
  Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5511-8. PMID: 27573832.
• Kiguchi N, Ding H, Ko MC*.
  Central N/OFQ-NOP Receptor System in Pain Modulation.
  Adv Pharmacol. 2016;75:217-43. Review. PMID: 26920014.
• Kiguchi N, Sukhtankar DD, Ding H, Tanaka K, Kishioka S, Peters CM, Ko MC*.
  Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.
  J Pharmacol Exp Ther. 2016 Mar;356(3):596-603. PMID: 26669425.
• Nakamoto T, Izu Y, Kawasaki M, Notomi T, Hayata T, Noda M, Ezura Y.
  Mice deficient in CIZ/NMP4 develop an attenuated from of K/BxN-serum induced arthritis.
  J Cell Biochem, 117: 4: 970-7, 2016.

In 2015

• Kobayashi S, Nakamura TY, Wakabayashi S*.
  Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.
  J. Mol. Cell. Cardiol., 2015, 84:133-42.
• Nakao S, Wakabayashi S, Nakamura, TY*.
  Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calcium sensor-1.
  PLoS ONE, 2015 10(4):e0125050.
• Kiguchi N, Saika F, Kobayashi Y, Ko MC, Kishioka S*.
  TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages.
  J Pharmacol Sci. 2015 Jun;128(2):83-6. PMID: 26012743.
• Kobayashi Y, Kiguchi N, Fukazawa Y, Saika F, Maeda T, Kishioka S*.
  Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.
  J Biol Chem. 2015 May 15;290(20):12603-13. PMID: 25787078.
• Kiguchi N, Kobayashi Y, Saika F, Sakaguchi H, Maeda T, Kishioka S*.
  Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain.
  Pain. 2015 Apr;156(4):684-93. PMID: 25630024.
• Saika F, Kiguchi N, Kobayashi Y, Kishioka S*.
  Peripheral alpha4beta2 nicotinic acetylcholine receptor signalling attenuates tactile allodynia and thermal hyperalgesia after nerve injury in mice.
  Acta Physiol (Oxf). 2015 Feb;213(2):462-71. PMID: 25491757.
• Yasuda J, Okada M, Yamawaki H.
  Endostatin inhibits T-type Ca2+ channel current in guinea pig ventricular myocyte.
  J. Vet. Med. Sci. 77: 1289-1291, 2015.
• Yasuda J, Takada L, Kajiwara Y, Okada M, Yamawaki H.
  Endostatin inhibits bradykinin-induced cardiac contraction.
  J. Vet. Med. Sci. 77: 1391-1395, 2015.
• Notomi T*, Kuno M, Hiyama A, Ezura Y, Honma M, Ishizuka T, Ohura K, Yawo H, Noda M.
  Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts.
  Bone, 81: 1: 306-14, 2015.
• Notomi T*, Kuno M, Hiyama A, Ohura K, Noda M, Skerry TM.
  Zinc-induced effects on osteoclastogenesis involves activation of hyperpolarization-activated cyclic nucleotide modulated channels via changes in membrane potential.
  J Bone Miner Res, 30: 9: 1618-26, 2015.
• Aryal S, Miyai K, Izu Y, Hayata T, Notomi T, Noda M, Ezura Y.
  Nck influences preosteoblastic/osteoblastic migration and bone mass.
  Proc Natl Acad Sci USA, 112: 50: 15432-7, 2015.
• Kawasaki M, Ezura Y, Hayata T, Notomi T, Izu Y, Noda M.
  TGF-Beta Suppresses Ift88 Expression in Chondrocytic ATDC5 cells.
  J Cell Physiol, 230: 11: 2788-95, 2015.
• Yamada T, Ezura Y, Hayata T, Moriya S, Shirakawa J, Notomi T, Aryal S, Kawasaki M, Izu Y, Harada K, Noda M.
  β2 Adrenergic receptor activation suppresses BMP-induced alkaline phosphatase expression in osteoblast-like MC3T3E1 cells.
  J Cell Biochem, 116: 6: 1144-52, 2015.
• Moriya S, Hayata T, Notomi T, Aryal S, Nakamoto T, Izu Y, Kawasaki M, Yamada T, Shirakawa J, Kaneko K, Ezura Y, Noda M.
  PTH regulates β2-adrenergic receptor expression in osteoblast-like MC3T3-E1 cells.
  J Cell Biochem, 116: 1: 142-8, 2015.
• 雑賀史浩, 木口倫一, 岸岡史郎.
  The role of CC-chemokine ligand 2 in the development of psychic dependence on methamphetamine.
  日本アルコール薬物医学会雑誌 2015; 50(5): 189-195.
• 小林悠佳, 木口倫一, 雑賀史浩, 岸岡史郎.
  Exploration of novel therapeutic targets for neuropathic pain based on the regulation of immune cells.
  日本神経精神薬理学雑誌 2015; 35(3): 65-72.
• 小林悠佳, 岸岡史郎.
  新規疼痛制御分子としてのマクロファージ由来マトリックスメタロプロテアーゼ12 の可能性.
  PAIN RESEARCH. 2015; 30(1): 37-45.